USING A SCALED LUNG MODEL TO INVESTIGATE THE DEPOSITION BEHAVIOUR OF AEROSOLS INCLUDING ALLICIN [Poster]

Allicin as an addition to conventional antibiotics? [Poster]

Borlinghaus, J., Foerster, J., Kappler, U., Antelmann, H., Noll, U., Gruhlke, M. C. H., Slusarenko, A. J. (2021). Allicin, the Odor of Freshly Crushed Garlic: A Review of Recent Progress in Understanding Allicin’s Effects on Cells. Molecules, 26, 1505.

Schultz, C. R., Gruhlke, M. C., Slusarenko, A. J., Bachmann, A. S. (2020). Allicin, a Potent New Ornithine Decarboxylase Inhibitor in Neuroblastoma Cells. Journal of Natural Products, 83(8), 2518-2527.

Schlembach, I., Uebachs, A., Caspers, T., Fragoulis, A., Slusarenko, A. J., Gruhlke, M. C. (2020). Effect of Prooxidative Natural Products: Comparison of the OSI1 (YKL071w) Promoter Luciferase Construct from Yeast with an Nrf2/Keap Reporter System. Applied Sciences, 10(10), 3520.

Borlinghaus, J., Reiter, J., Ries, M., Gruhlke, M. C. H. (2020). Screening procedures and tests for antioxidants. In Pathology (Oxidative Stress and Dietary Antioxidants), Rajendram, R., Patel, V. B., Preedy, V. R. eds., Academic Press, pp 397-401.

Dörner, P., Müller, P. M., Reiter, J., Gruhlke, M. C., Slusarenko, A. J., Schröder, W., Klaas, M. (2020). Feasibility study of a surface-coated lung model to quantify active agent deposition for preclinical studies. Clinical Biomechanics, 105029.

Borlinghaus, J., Bolger, A., Schier, C., Vogel, A., Usadel, B., Gruhlke, M. C., Slusarenko, A. J. (2020). Genetic and molecular characterization of multicomponent resistance of Pseudomonas against allicin. Life science alliance, 3(5).

Sarfraz, M., Nasim, M. J., Jacob, C., Gruhlke, M. C. (2020). Efficacy of Allicin against Plant Pathogenic Fungi and Unveiling the Underlying Mode of Action Employing Yeast Based Chemogenetic Profiling Approach. Applied Sciences, 10(7), 2563.

Reiter, J., Hübbers, A. H., Albrecht, F., Leichert, L. I. O., Slusarenko, A. J. (2020) Allicin, a natural antimicrobial defence substance from garlic, inhibits DNA gyrase activity in bacteria. International Journal of Medical Microbiology, 310(1), 151359.

Reiter, J., Borlinghaus, J., Dörner, P., Schröder, W., Gruhlke, M. C., Klaas, M., Slusarenko, A. J. (2020). Investigation of the deposition behaviour and antibacterial effectivity of allicin aerosols and vapour using a lung model. Experimental and Therapeutic Medicine, 19(2), 1541-1549.

Horn, T., Bettray, W., Noll, U., Krauskopf, F., Huang, M.-R., Bolm, C., Slusarenko, A.J., Gruhlke, M. C. H. (2020) The Sulfilimine Analogue of Allicin, S-Allyl-S-(S-allyl)-N-Cyanosulfilimine, Is Antimicrobial and Reacts with Glutathione. Antioxidants 9, 1086.

Chi, B. K., Huyen, N. T. T., Loi, V. V., Gruhlke, M. C. H., Schaffer, M., Mäder, U., Maaß, S., Becher, D., Bernhardt, J., Arbach, M., Hamilton, C., Slusarenko, A. J., Antelmann, H. (2019). The disulfide stress response and protein S-thioallylation caused by allicin and diallyl polysulfanes in Bacillus subtilis as revealed by transcriptomics and proteomics. Antioxidants, 8(12), 605.

Sarfraz, M., Nasim, M. J., Jacob, C., Gruhlke, M. C. (2019). Yeast Chemogenetic Screening as a Tool to Unravel the Antifungal Mode of Action of Two Selected Selenocyanates. Applied Sciences, 9(18), 3728.

Gruhlke, M. C. (2019). Reactive Sulfur Species: A New Player in Plant Physiology? In: Reactive Oxygen, Nitrogen and Sulfur Species in Plants: Production, Metabolism, Signaling and Defense Mechanisms, John Wiley & Sons Ltd., pp 715-728.

Van Loi, V., Huyen, N. T. T., Busche, T., Tung, Q. N., Gruhlke, M. C. H., Kalinowski, J., Bernhardt, J., Slusarenko, A. J., Antelmann, H. (2019). Staphylococcus aureus responds to allicin by global S-thioallylation–role of the Brx/BSH/YpdA pathway and the disulfide reductase MerA to overcome allicin stress. Free Radical Biology and Medicine, 139, 55-69.

Gruhlke, M. C. (2019). Thiol-Modification as Important Mode of Action for Allicin from Garlic (Allium sativum). In: Multidisciplinary Digital Publishing Institute Proceedings, Vol. 11 (1), 27.

Leontiev, R., Hohaus, N., Jacob, C., Gruhlke, M. C., Slusarenko, A. J. (2018). A comparison of the antibacterial and antifungal activities of thiosulfinate analogues of allicin. Scientific reports, 8(1), 1-19.

Gruhlke, M. C., Antelmann, H., Bernhardt, J., Kloubert, V., Rink, L., Slusarenko, A. J. (2019). The human allicin-proteome: S-thioallylation of proteins by the garlic defence substance allicin and its biological effects. Free Radical Biology and Medicine, 131, 144-153.

Horn, T., Bettray, W., Slusarenko, A. J., Gruhlke, M. C. (2018). S-allylmercaptoglutathione is a substrate for glutathione reductase (EC 1.8. 1.7) from yeast (Saccharomyces cerevisiae). Antioxidants, 7(7), 86.

Gruhlke, M. C. H., Slusarenko, A. J. (2018). The Chemistry of Alliums. Molecules, 23, 143.

Reiter, J., Levina, N., Van der Linden, M., Gruhlke, M., Martin, C., Slusarenko, A. J. (2017). Diallylthiosulfinate (allicin), a volatile antimicrobial from garlic (Allium sativum), kills human lung pathogenic bacteria, including MDR strains, as a vapor. Molecules, 22(10), 1711.

Gruhlke, M. C., Schlembach, I., Leontiev, R., Uebachs, A., Gollwitzer, P. U., Weiss, A., Delaunay, A., Toledano, M., Slusarenko, A. J. (2017). Yap1p, the central regulator of the S. cerevisiae oxidative stress response, is activated by allicin, a natural oxidant and defence substance of garlic. Free Radical Biology and Medicine, 108, 793-802.

Gruhlke, M. C., Nicco, C., Batteux, F., Slusarenko, A. J. (2017). The effects of allicin, a reactive sulfur species from garlic, on a selection of mammalian cell lines. Antioxidants, 6(1), 1.

Albrecht, F., Leontiev, R., Jacob, C., Slusarenko, A. J. (2017) An optimized facile procedure to synthesize and purify allicin. Molecules 22(5), 770.

Sillapawattana, P., Gruhlke, M. C., Schäffer, A. (2016). Effect of silver nanoparticles on the standard soil arthropod Folsomia candida (Collembola) and the eukaryote model organism Saccharomyces cerevisiae. Environmental Sciences Europe, 28(1), 1-12.

Gruhlke, M. C., Hemmis, B., Noll, U., Wagner, R., Lühring, H., Slusarenko, A. J. (2015). The defense substance allicin from garlic permeabilizes membranes of Beta vulgaris, Rhoeo discolor, Chara corallina and artificial lipid bilayers. Biochimica et Biophysica Acta (BBA)-General Subjects, 1850(4), 602-611.

Gruhlke, M. C. H., Slusarenko, A. J. (2014). The cellular ‘thiolstat’as an emerging potential target of some plant secondary metabolites. In Recent Advances in Redox Active Plant and Microbial Products, Springer, Dordrecht, pp 235-262.

Mániková, D., Letavayová, L. M., Vlasáková, D., Košík, P., Estevam, E. C., Nasim, M. J., Gruhlke, M., Slusarenko, A., Burkholz, T., Jacob. C., Chovanec, M. (2014). Intracellular diagnostics: Hunting for the mode of action of redox-modulating selenium compounds in selected model systems. Molecules, 19(8), 12258-12279.

Borlinghaus, J., Albrecht, F., Gruhlke, M. C., Nwachukwu, I. D., Slusarenko, A. J. (2014). Allicin: chemistry and biological properties. Molecules, 19(8), 12591-12618.

Perelló, A., Gruhlke, M., Slusarenko, A. J. (2013). Effect of garlic extract on seed germination, seedling health, and vigour of pathogen-infested wheat. Journal of Plant Protection Research, 53(4), 317-323.

Doering, M., Diesel, B., Gruhlke, M. C., Viswanathan, U. M., Mániková, D., Chovanec, M., Burkholz, T., Slusarenko, A. J., Kiemer, A. K., Jacob, C. (2012). Selenium-and tellurium-containing redox modulators with distinct activity against macrophages: possible implications for the treatment of inflammatory diseases. Tetrahedron, 68(51), 10577-10585.

Gruhlke, M. C. H., Slusarenko, A. J. (2012). The biology of reactive sulfur species (RSS). Plant Physiology and Biochemistry, 59, 98-107.

Haase, H., Hieke, N., Plum, L. M., Gruhlke, M. C., Slusarenko, A. J., Rink, L. (2012). Impact of allicin on macrophage activity. Food chemistry, 134(1), 141-148.

Nwachukwu, I. D., Slusarenko, A. J., Gruhlke, M. C. (2012). Sulfur and sulfur compounds in plant defence. Natural product communications, 7(3), 1934578X1200700323.

Gruhlke, M. C., Portz, D., Stitz, M., Anwar, A., Schneider, T., Jacob, C., Schlaich, N. L., Slusarenko, A. J. (2010). Allicin disrupts the cell’s electrochemical potential and induces apoptosis in yeast. Free Radical Biology and Medicine, 49(12), 1916-1924.

Curtis, H., Noll, U., Störmann, J., Slusarenko, A.J. (2004) Broad-spectrum activity of the volatile phytoanticipin allicin in extracts of garlic (Allium sativum L.) against plant pathogenic bacteria, fungi and Oomycetes. Physiological and Molecular Plant Pathology, 65 (2), 79–89.